Dynamic Release System

The concept of Dynamic Release System is illustrated below. Even though the prodrug is bioactivated in the non-inflamed area (A), some of it keep progressing to the active site of inflammation (B) where the presence of blood activates the prodrug. This results in a significant increase in the rate of enzymatic break down and therefore, a higher local concentration of the parent anti-inflammatory agent (Dynamic Release System or disease-inducible bioactivation).    

Dynamic Release System: the rate of prodrug bioactivation significantly increases at the site of inflammation