Dynamic Release System
The ultimate level of precision for drug delivery
The concept of Dynamic Release System (disease-inducible bioactivation) is illustrated below. Even though the prodrug is bioactivated in the non-inflamed area (A), some of it keep progressing to the active site of inflammation (B) where the presence of blood, from colon mucosa ulceration, activates the prodrug. This results in a significant increase in the rate of enzymatic break down and therefore, a higher local concentration of the parent anti-inflammatory agent.